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上海交大生命科学技术学院研究生导师简介:夏小霞(生物工程系)

来源:www.sjtuky.com 作者:鸿知上交大考研网 浏览:48 次 发布时间:2018/12/3

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上海交大生命科学技术学院研究生导师简介:夏小霞(生物工程系)


基本信息

姓名:夏小霞

职称:特别研究员

E-Mail:xiaoxiaxia@sjtu.edu.cn


个人简介

上海交通大学特别研究员,博士生导师。20091月获韩国科学技术院(KAIST)化学与生物分子工程博士学位,之后在韩国KAIST及美国Tufts大学从事博士后研究,于20129月加入上海交通大学,并被授予上海高校特聘教授(东方学者)称号,且入选上海市浦江人才计划(A类)。

主要研究先进功能材料的设计与微生物合成,在PNASAdvancedMaterialsBiomacromolecules等国际期刊发表SCI研究论文42篇,代表性人工蜘蛛丝研究成果被NatureChemicalBiology和麻省理工学院出版的TechnologyReview以“新闻和观点”和专题等形式作了评论和推介,获得美国、澳大利亚等国家发明专利授权10余项,应邀在包括2017年国际合成生物学大会、2015年哥本哈根生物科学会议等有影响的国际会议作学术报告10余次,并担任国际期刊BiotechnologyJournalACSBiomaterialsScience&Engineering编委。


研究方向

先进材料的仿生合成

新型智能生物材料的设计与合成

蛋白生物材料的高效生物制造及应用

 

发表论文

ZhouZ†,ZhangS†,MarelliB*,XiaXX*,TaoTH*.Engineeringthefutureofsilkmaterialsthroughadaptablemodificationandadvancedmanufacturing.AdvMater,2018,DOI:10.1002/adma.201706983.

JiangJ†,ZhangS†,QianZ,QinN,SongW,SunL,ZhouZ,ShiZ,ChenL,LiX,MaoY,KaplanDL,GilbertCorderSN,ChenX,LiuM,OmenettoFG,XiaXX*,TaoTH*.Proteinbricks:2Dand3Dbio-nanostructureswithshapeandfunctionondemand.AdvMater,2018,DOI:10.1002/adma.201705919(Selectedasinsidebackcover).

ChenXF,XiaXX,LeeSY,QianZG*.EngineeringtunablebiosensorsformonitoringputrescineinEscherichiacoli.BiotechnolBioeng,2018,115(4):1014-1027.

YuJL,XiaXX,ZhongJJ*,QianZG*.EnhancedproductionofC5dicarboxylicacidsbyaerobic-anaerobicshiftinfermentationofengineeredEscherichiacoli.ProcessBiochem,2017,62:53-58.

JiangH,XiaXX,FengY,ZhongJJ,QianZG*.Developmentofarobustsystemforhigh-throughputcolorimetricassayofdiverseaminoaciddecarboxylases.ProcessBiochem,2017,60:27-34.

YuJL,XiaXX,ZhongJJ*,QianZG*.AnovelsyntheticpathwayforglutarateproductioninrecombinantEscherichiacoli.ProcessBiochem,2017,59:167-171.

HuangSC†,QianZG†,DanAH,HuX,ZhouML,XiaXX*.Rationaldesignandhierarchicalassemblyofageneticallyengineeredresilin-slikcopolymerresultsinstiffhydrogels.ACSBiomaterSciEng,2017,3(8):1576-1585.

QiaoX,QianZ,LiJ,SunH,HanY,XiaXX,ZhouJ,WangC,WangY*,WangC*.Syntheticengineeringspidersilkfiberasimplantableopticalwaveguidesforlow-losslightguiding.ACSApplMaterInterfaces,2017,9(17):14665-14676.

ChenL,ZhouML,QianZG,KaplanDL,XiaXX*.Fabricationofproteinfilmsfromgeneticallyengineeredsilk-elastin-likeproteinsbycontrolledcross-linking.ACSBiomaterSciEng,2017,3(3):335-341.

ZhouML,QianZG,ChenL,KaplanDL,XiaXX*.Rationallydesignedredox-sensitiveproteinhydrogelswithtunablemechanicalproperties.Biomacromolecules,2016,17(11):3508-3515.

PengQ†,ZhangY†*,LuL,ShaoH,QinK,HuX,XiaXX*.Recombinantspidersilkfromaqueoussolutionsviaabio-inspiredmicrofluidicchip.SciRep,2016,6:36473.

QinN†,ZhangS†,JiangJ,CorderSG,QianZ,ZhouZ,LeeW,LiuK,WangX,LiX,ShiZ,MaoY,BechtelHA,MartinMC,XiaXX,MarelliB,KaplanDL,OmenettoFG*,LiuM*,TaoTH*.Nanoscaleprobingofelectron-regulatedstructuraltransitionsinsilkproteinsbynear-fieldIRimagingandnano-spectroscopy.NatCommun,2016,7:13079.

HuangW,TarakanovaA,DinjaskiN,WangQ,XiaXX,ChenY,WongJY,BuehlerMJ,KaplanDL*.Designofmultistimuliresponsivehydrogelsusingintegratedmodelingandgeneticallyengineeredsilk-elastin-like-proteins.AdvFunctMater,2016,26(23):4113-4123.

YangYX,QianZG,ZhongJJ*,XiaXX*.Hyper-productionoflargeproteinsofspiderdraglinesilkMaSp2byEscherichiacoliviasyntheticbiologyapproach.ProcessBiochem,2016,51(4):484-490.(Editors’Choicepaper)

QianZG†,ZhouML†,SongWW,XiaXX*.DualthermosensitivehydrogelsassembledfromtheconservedC-terminaldomainofspiderdraglinesilk.Biomacromolecules,2015,16(11):3704-3711.

QiK,XiaXX,ZhongJJ*.Enhancedanti-oxidativeactivityandlignocellulosicethanolproductionbybiotinadditiontomediuminPichiaguilliermondiifermentation.BioresourceTechnol,2015,189:36-43.

YuJL,XiaXX,ZhongJJ*,QianZG*.DirectbiosynthesisofadipicacidfromasyntheticpathwayinrecombinantEscherichiacoli.BiotechnolBioeng,2014,111(12):2580-2586.

XuYN,XiaXX,ZhongJJ*.InductionofganodericacidbiosynthesisbyMn2+instaticliquidcultivationofGanodermalucidum.BiotechnolBioeng,2014,111(11):2358-2365.

QiK,ZhongJJ*,XiaXX*.TriggeringrespirofermentativemetabolismintheCrabtree-negativeyeastPichiaguilliermondiibydisruptingtheCAT8Gene.ApplEnvironMicrobiol,2014,80(13):3879-3887.

XiaX,LinS,XiaXX,CongFS,ZhongJJ*.SignificanceofagitationinducedshearstressonmyceliummorphologyandlavendamycinproductionbyengineeredStreptomycesflocculus.ApplMicrobiolBiotechnol,2014,98(10):4399-4407.

WangQ†,XiaXX†,HuangW,LinY,XuQ,KaplanDL*.Highthroughputscreeningofdynamicsilk-elastin-likeproteinbiomaterials.AdvFunctMater,2014,24(27):4303-4310.

LinY†,XiaXX†,WangM†,WangQ,AnB,TaoH,XuQ,KaplanDL*.Geneticallyprogrammablethermoresponsiveplasmonicgold/silk-elastinproteincore/shellnanoparticles.Langmuir,2014,30(15):4406-4414.

XiaXX†,WangM†,LinY,XuQ,KaplanDL*.Hydrophobicdrug-triggeredself-assemblyofnanoparticlesfromsilk-elastin-likeproteinpolymersfordrugdelivery.Biomacromolecules,2014,15(3):908-914.

DouY,XiaoJH*,XiaXX,ZhongJJ*.EffectofoxygensupplyonbiomassandhelvolicacidproductioninsubmergedfermentationofCordycepstaii.BiochemEngJ,2013,81:73-79.

HuX,Tang-SchomerMD,HuangW,XiaXX,WeissAS,KaplanDL*.Charge-tunableautoclavedsilk-tropoelastinproteinalloysthatcontrolneuroncellresponses.AdvFunctMater,2013,23(31):3875-3884.

LinY,XiaXX,ShangK,EliaR,HuangW,CebeP,LeiskG,OmenettoF,KaplanDL*.Tuningchemicalandphysicalcross-linksinsilkelectrogelsformorphologicalanalysisandmechanicalreinforcement.Biomacromolecules,2013,14(8):2629-2635.

XuYN,XiaXX,ZhongJJ*.InducedeffectofNa+onganodericacidbiosynthesisinstaticliquidcultureofGanodermalucidumviacalcineurinsignaltransduction.BiotechnolBioeng,2013,110(7):1913-1923(Spotlightpaper,seeDOI:10.1002/bit.24670).

FanC,QiK,XiaXX*,ZhongJJ*.Efficientethanolproductionfromcorncobresiduesbyrepeatedfermentationofanadaptedyeast.BioresourceTechnol,2013,136:309-315.

SunZ,QinG,XiaXX,Mark,CG,Omenetto,F,KaplanDL*.Photoresponsiveretinal-modifiedsilk-elastincopolymer.JAmChemSoc,2013,135(9):3675-3679.

AnB,DesRochersTM,QinG,XiaXX,ThiagarajanG,BrodskyB,KaplanDL*.Theinfluenceofspecificbindingofcollagen-silkchimerastosilkbiomaterialsonhMSCbehavior.Biomaterials,2013,34(2):402-412.

YoonSH,HanMJ,JeongH,LeeCH,XiaXX,LeeDH,ShimJH,LeeSY,OhTK,KimJF*.Comparativemulti-omicssystemsanalysisofEscherichiacolistrainsBandK-12.GenomeBiol,2012,13(5):1-13.

HuX,ParkSH,GilES,XiaXX,WeissAS,KaplanDL*.Theinfluenceofelasticityandsurfaceroughnessonmyogenicandosteogenic-differentiationofcellsonsilk-elastinbiomaterials.Biomaterials,2011,32(34):8979-8989.

XiaXX,XuQ,HuX,QinG,KaplanDL*.Tunableself-assemblyofgeneticallyengineeredsilk-elastinproteinpolymers.Biomacromolecules,2011,12(11):3844-3850.

XiaXX,QianZG,LeeSY*.ComparativeproteomicandgeneticanalysesrevealunidentifiedmutationsinEscherichiacoliXL1-BlueandDH5α.FEMSMicrobiolLett,2011,314(2):119-124.

QianZG,XiaXX,LeeSY*.MetabolicengineeringofEscherichiacolifortheproductionofcadaverine:Afivecarbondiamine.BiotechnolBioeng,2011,108(1):93-103.

XiaXX†,QianZG†,KiCS,ParkYH,KaplanDL,LeeSY*.Native-sizedrecombinantspidersilkproteinproducedinmetabolicallyengineeredEscherichiacoliresultsinastrongfiber.ProcNatlAcadSciUSA,2010,107(32):14059-14063.

NewsandViewsinNatureChemicalBiology(LinkeWA.Biomaterials:Spiderstrengthandstretchability.NatureChemicalBiology6:702-703;October2010)

FeaturedbyMITTechnologyReview(3August2010)

QianZG,XiaXX,LeeSY*.MetabolicengineeringofEscherichiacolifortheproductionofputrescine:Afourcarbondiamine.BiotechnolBioeng,2009,104(4):651-662.

Editors'Choice,Journalcoverpaper;Wiley-BlackwellPressRelease‘Pioneeringresearchsucceedsinproducingindustriallyvitalchemicalthroughengineeredbacteria’(27Aug.2009);NatureResearchHighlight‘Bacterialfactories’(Nature461,14-15;3September2009);BTJ-FORUM‘MetabolicengineeringofE.coli’(BiotechnologyJournal,2009,4:1376).

QianZG†,XiaXX†,LeeSY*.Proteome-basedidentificationoffusionpartnerforhigh-levelextracellularproductionofrecombinantproteinsinEscherichiacoli.BiotechnolBioeng,2008,101(3):587-601.

Spotlight‘Aproteome-basedapproachtoidentifyingfusionpartnerforrecombinantproteinexcretion’(BiotechnologyandBioengineeringDOI:10.1002/bit.22096).

XiaXX,HanMJ,LeeSY*,YooJS.ComparisonoftheextracellularproteomesofEscherichiacoliBandK-12strainsduringhighcelldensitycultivation.Proteomics,2008,8(1):2089-2103.

ShenYL*,ZhangY,SunAY,XiaXX,WeiDZ*,YangSL.High-levelproductionofsolubletumornecrosisfactor-relatedapoptosis-inducingligand(Apo2L/TRAIL)inhigh-densitycultivationofrecombinantEscherichiacoliusingacombinedfeedingstrategy.BiotechnolLett,2004,26:981-984.

XiaXX,ShenYL*,WeiDZ*.PurificationandcharacterizationofrecombinantsTRAILexpressedinEscherichiacoli.ActaBiochBiophSin,2004,36(2):118-122.

ShenYL*,XiaXX,ZhangY,LiuJW,WeiDZ*,YangSL.RefoldingandpurificationofApo2L/TRAILproducedasinclusionbodiesinhigh-cell-densityculturesofrecombinantEscherichiacoli.BiotechnolLett,2003,25(24):2097-2101.


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